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. 2013 Nov 15;27(22):2439–2444. doi: 10.1101/gad.227165.113

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© 2013 Kumar et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 3.0 Unported), as described at http://creativecommons.org/licenses/by-nc/3.0/.

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Figure 3. — A developmentally stage-specific chromatin configuration of the Igh locus. 5C analyses of the Igh locus in Rag 2^−/− pro-B cells and resting splenic B cells are represented in heat maps of 5C data (bin size 30 kb; step size 3.0 kb). Interaction frequencies are plotted against genomic distance. Blue intensity represents the contact frequency between genomic coordinates. The diagonal represents frequent proximal intrachromosomal interactions along the linear Igh locus. 5C signals off the diagonal indicate looping interactions. (Right panel) Log₂ ratio of pro-B/resting B 5C interactions where pro-B (red) and resting B (blue) contact.