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. 2013 Nov 15;27(22):2439–2444. doi: 10.1101/gad.227165.113

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© 2013 Kumar et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 3.0 Unported), as described at http://creativecommons.org/licenses/by-nc/3.0/.

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Figure 4. — Absence of IgG3 and IgG1 CSR in pro-B cells is related to looping interactions between the γ3 and γ1 loci. (A) A segment of the Igh locus spanning 220 kb (shown at the top) in which 3C HindIII restriction fragments (A, B, C, D, and H) are shown. (B,C) 3C assays using chromatin from Rag2^−/− pro-B cells, unstimulated (US) or LPS+CD40L (LC)-stimulated 445.3 cells, wild-type (WT) resting splenic B cells, or ConA-stimulated T cells. (*) P ≤ 0.05; (ns) Not significant. (B) 3C assays anchored at γ3 were analyzed for interactions with γ1 or γ2b. (C) Hs3b,4 (3′Eα) anchor was analyzed for interactions with Eμ, γ3, or γ2b.