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. 2013 Sep 17;45(22):1109–1122. doi: 10.1152/physiolgenomics.00108.2013

Fig. 1.

Fig. 1.

Congenic intervals containing arthritis severity quantitative trait loci (QTL) and their effect on arthritis severity. A: Cia3d and Cia5a congenics have a DA/Arb background and F344 alleles only on segments of chromosomes 4 and 10, respectively. Cia25 and Cia10 congenics have a DA/Hsd background and ACI alleles only on segments of chromosomes 12 and 2, respectively. B: at day 21 postarthritis induction DA/Arb and DA/Hsd rats developed similarly severe arthritis, while all 4 congenic strains were protected and had a significantly milder form of arthritis. **P ≤0.001 for each congenic vs. DA, Mann-Whitney.