Fig. 6.

Upstream regulators with increased activity in DA and reduced activity in the congenics. IL-6 (A), IL-17A (B), PDGF (C), and STAT3 (D) were among the upstream regulators with the highest z-scores and P values, suggesting increased activity in DA and reduced activity in congenics. Orange lines with arrows indicate effect that increases expression or activity, while blue lines with vertical dash indicate an effect that decreases expression or activity. Green line and a combination of arrow plus dash indicate mixed activity or activity that, based on the literature varies, according to experimental conditions.