Fig. 7.

Upstream regulators MyD88 and TLR7 had a predicted increased activity in DA. MyD88 (A), a key mediator of signaling through most of the TLRs, and several TLRs such as TLR7 (B) and their ligands were among the upstream regulators with the highest z-scores and P values, suggesting increased activity in DA and reduced activity in congenics. Orange lines with arrows indicate effect that increases expression or activity, while blue lines with vertical dash indicate an effect that decreases expression or activity. Green line and a combination of arrow plus dash indicate mixed activity, or activity that, based on the literature, varies according to experimental conditions.