Table 3.
Gene functional categories expressed in increased levels in synovial tissues from DA or in the combined congenic rats
| Category | Genes |
|---|---|
| DA | |
| Cytokines and related genes | Il1β, Il6*, Il18, Ltb, Il13ra2, Il17a*, Il17ra, Il4ra, Litaf, Jak2 |
| Chemokines and receptors | Ccl2, Ccl7, Cxcl1, Cxcl13, Ccr5 |
| Class II MHC | CD74, HLA-DMA, HLA-DMB, HLA-DQA1, HLA-DRA, HLA-DRB1 |
| Phagocytosis | Fcer1 g, Fcgr1a, Fcgr3a, Fcrls |
| Oxidative metabolism | Ncf1, Ncf4, Sod2 |
| DAMPs and PRRs | Cd14, Cd68, Cd163, Tlr2, Clec7a, Clec4a1, Clec4a3, Clec10a, Mrc1, Pycard |
| Adhesion molecules | CD44, Clec4m, Itgam, Itgb2, Itgb7, Lman1, Selp |
| Proteases | Adamts1, Mmp3, Mmp9, Mmp14, Plau |
| ECM components | Col1a1, Col3a1, Col5a1, Col5a2, Col11a1, Col16a1, Emilin1, Tnn, Vcan |
| ECM synthesis | Has1, Has2, Lox, Loxl3, Pcolce, Plod2 |
| Cell cycle | Ccnb2, Cks2, Cdc20, Cenpk, Cdca8, Chek2, Fos |
| Congenic strains | |
| Detoxification | Adh1, Cyb561, Cyb5r2, Cyb5r3, Cyp2j3, Cyp26b1, Cyp27a1, Mt3, Phyh, Tst |
| Lipid metabolism | Adipoq, Dgat1, Dgat2, Lipe, Lpin1, Lpl, Mgll, Plin1, Scd1 |
| Oxidative metabolism | Cat, Gstk1, Gstm1, Gstm2, Gstm7, Gstp1, Gstt1, Gstt2 |
*
Results from quantitative (q)PCR. DAMPs, damage-associated molecular patterns; PRRs, pattern recognition receptors; ECM, extracellular matrix.