Table 4.

Selected predicted upstream regulators for DA and congenic rats

Activated in	Upstream Regulator	Molecule Type	z-Score	P Value of Overlap
DA	TNF	cytokine	6.83	3.39 × 10−33
	LPS	chemical drug	6.07	1.33 × 10−24
	IFNG	cytokine	5.43	4.09 × 10−17
	TGFB1	growth factor	4.86	4.51 × 10−23
	IL1B	cytokine	4.85	4.42 × 10−13
	MYD88	cell signaling	4.46	4.85 × 10−08
	IL6	cytokine	4.26	1.74 × 10−14
	Poly rI:rC RNA	chemical reagent	3.81	3.49 × 10−09
	STAT3	transcription regulator	3.68	9.33 × 10−21
	RELA	transcription regulator	3.67	3.38 × 10−09
	TNFSF12	cytokine	3.61	2.68 × 10−07
	LEP	growth factor	3.53	4.85 × 10−09
	ERK1/2	cell signaling	3.52	8.04 × 10−07
	TLR4	transmembrane receptor	3.50	2.82 × 10−06
	Jnk	cell signaling	3.46	2.20 × 10−07
	BCR (complex)	complex	3.39	2.25 × 10−04
	NFkB (complex)	complex	3.36	1.20 × 10−09
	IL17A	cytokine	2.66	1.09 × 10−07
	cigarette smoke	chemical toxicant	2.99	5.11 × 10−05
	carrageenan	chemical - nonmammalian	2.58	3.58 × 10−05
Congenics	PPARG	ligand-dependent nuclear receptor	4.15	2.13 × 10−16
	PPARA	ligand-dependent nuclear receptor	2.38	1.51 × 10−18
	PPARD	ligand-dependent nuclear receptor	2.87	9.02 × 10−05
	GW3965	LXR agonist	3.20	7.78 × 10−07
	NR1H3/LXRA	ligand-dependent nuclear receptor	2.69	1.10 × 10−04
	L-triiodothyronine/THR	chemical - endogenous mammalian	2.65	2.00 × 10−09
	dexamethasone/GR	chemical drug	3.69	5.80 × 10−23
	SB203580	p38 MAPK inhibitor	3.27	2.23 × 10−16
	U0126	ERK inhibitor	3.38	3.09 × 10−06
	PD98059	chemical - kinase inhibitor	2.90	6.07 × 10−17
	TP53	transcription regulator	2.14	1.65 × 10−16
	let-7	microRNA	2.98	3.70 × 10−02
	diphenyleneiodonium	chemical drug	3.79	1.08 × 10−11
	N-acetyl-L-cysteine	chemical drug	2.41	5.92 × 10−09
	APOE	transporter	2.54	1.80 × 10−12
	resveratrol	chemical drug	2.84	8.09 × 10−08
	valsartan	chemical drug	2.40	5.94 × 10−10