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. 2013 Nov 27;7:230. doi: 10.3389/fncel.2013.00230

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Copyright © 2013 Engbers, Anderson, Zamponi and Turner.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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A reduced model of the roles for I_T and I_H in rebound response frequency and FSL. (A–D), Output from a two compartment model containing combinations of I_T and/or I_H, with representative spike output following a 300 ms hyperpolarizing step to -77 mV from a resting potential of ~-60 mV (10 Hz baseline firing) (left). Changes in frequency and FSL/ISI are plotted in three dimensions in relation to the frequency and ISI present at a resting membrane potential of ~-60 mV. Note a decrease in FSL/ISI and increase in frequency with longer durations or larger amplitude hyperpolarizations when both I_T and I_H are present (A). Removing I_T dramatically abolishes all rebound responses (B), while removing I_H reverses the FSL/ISI relationship and reduces rebound frequency (C). Removing both I_T and I_H blocks the shifts in both FSL/ISI and spike frequency found when both are present (D).