Table 1.

Intrinsic membrane properties of GP neurons in Pitx3WT and Pitx3Null mice

Mouse Type	Cell Type	Input Resistance, MΩ	Membrane Time Constant, ms	AP Base Duration, ms	AP Amplitude, mV	AP Threshold, mV	fAHP Amplitude, mV	Ih Sag, mV (trough potential, mV)
Pitx3WT	Type A	373.8 ± 28.7 (166.3–705.8) n = 37	37.4 ± 2.3 (14.2–66.9) n = 37	1.34 ± 0.06 (0.92–1.86) n = 37	70.5 ± 1.8 (54.0–91.0) n = 37	−41.1 ± 0.7 (−34.2 to −50.0) n = 37	−17.4 ± 0.7 (−11.0 to −24.6) n = 37	8.9 ± 0.7 (n = 25) (at −100.1 + 0.9) (6.1–14.0)
Pitx3WT	Type B	167.2 ± 10.5 (81.9–253.6) n = 26	20.2 ± 1.8 (14.6–33.8) n = 26	0.73 ± 0.01 (0.61–0.89) n = 26	71.4 ± 1.8 (53.3–89.5) n = 26	−43.3 ± 1.1 (−31.6 to −58.4) n = 26	−21.5 ± 0.8 (−16.4 to −30.5) n = 26	4.8 ± 0.6 (n = 11) (at −97.7 + 0.9) (2.7–7.7)
Pitx3Null	Type A	377.6 ± 24.7 (170.4–720.9) n = 35	37.2 ± 2.5 (15.2–73.8) n = 35	1.38 ± 0.04 (0.95–1.83) n = 35	70.8 ± 1.4 (58.6–90.9) n = 35	−40.2 ± 0.7 (−35.2 to −51.4) n = 35	−17.6 ± 0.6 (−10.8 to −24.5) n = 35	8.8 ± 0.6 (n = 31) (at −100.1 + 0.9) (6.4–12.5)
Pitx3Null	Type B	171.7 ± 10.4 (96.8–286.5) n = 30	21.1 ± 1.3 (12.0–33.3) n = 30	0.72 ± 0.02 (0.51–0.88) n = 30	71.2 ± 1.2 (53.3–90.7) n = 30	−43.4 ± 0.8 (−38.1 to −56.1) n = 30	−21.1 ± 0.7 (−16.5 to −34.8) n = 30	4.9 ± 0.5 (n = 14) (at −98.8 + 1.2) (3.0–6.9)
Pitx3WT vs. Pitx3Null	Type A	P > 0.05	P > 0.05	P > 0.05	P > 0.05	P > 0.05	P > 0.05	P > 0.05
	Type B	P > 0.05	P > 0.05	P > 0.05	P > 0.05	P > 0.05	P > 0.05	P > 0.05
Type A vs. type B	WT	P < 0.001	P < 0.05	P < 0.001	P > 0.05	P > 0.05	P < 0.05	P < 0.01
	Homo	P < 0.001	P < 0.05	P < 0.001	P > 0.05	P > 0.05	P < 0.05	P < 0.01

Values are means ± SE for n cells. Values in parentheses indicate ranges of individual values. GP, globus pallidus; AP, action potential; fAHP, fast afterhyperpolarization; WT, wild type; Homo, Pitx3Null. P values are from unpaired t-tests.