Fig. 5.

Light adaptation alters the timing of the L-IPSC in only OFF1,2,4 BCs, while the magnitude of L-IPSCs remains unaffected for each BC group. A and B: example L-IPSCs from an OFF1/2 and an OFF3 BC, respectively, in response to a 30-ms flash of light (dark gray bar below L-IPSC trace). There was no significant reduction of the dark-adapted L-IPSC with light adaptation. Recording paradigm is shown on left. C: intensity-response curves of charge transfer normalized to the max dark-adapted L-IPSC in OFF1,2,4 (n = 13) and OFF3 (n = 12) dark- and light-adapted L-IPSCs. There was no significant difference in the charge transfer between OFF1,2,4 and OFF3 BCs with light adaptation. D: normalized change in L-IPSC response parameters of OFF1,2,4 (n = 13) and OFF3 (n = 10) BCs to max dark-adapted response with light adaptation. The peak amplitude was significantly reduced, while the decay time was significantly increased in OFF1,2,4 BCs. In OFF3 BCs, neither the peak amplitude nor the decay time changed significantly. *P < 0.05, **P < 0.01.