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. 2013 Nov 27;7:191. doi: 10.3389/fncir.2013.00191

FIGURE 4.

FIGURE 4

Suppression effects by kinase inhibitors on CORT-induced changes in the density of thorns.(A) A 1 h treatment in ACSF without drugs (Control), with 1 μM CORT (CORT), with 1 μM CORT and 20 μM PD98059 (MAPK inhibitor; CORT + PD), with 1 μM CORT and 10 μM H-89 (PKA inhibitor; CORT + H89), with 1 μM CORT and 10 μM chelerythrine (PKC inhibitor; CORT + Chel), and with 1 μM CORT and 10 μM GSK-3β Inhibitor VIII (CORT + I8). (B) No effect of kinase inhibitors alone on the density of thorns in CA3 neurons. Abbreviations are the same as (A). Vertical axis is the average number of thorns per 1 μm of dendrite. Results are reported as mean ± SEM. The significance of CORT or drug effect was examined using the Tukey–Kramer post hoc multiple comparisons test when one way ANOVA tests yielded P < 0.05. **P < 0.01 vs. Control. #P < 0.05, ##P < 0.01 vs. CORT. For each drug treatment, we investigated 3 rats, 6 slices, 12 neurons, 12 dendrites, and 1600–1800 thorns.