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Model illustration. (A) Schematic illustration of CORT-driven multiple kinase pathways. Upon binding of CORT, GR induces the sequential activation of PKA, PKC, MEK, and Erk MAPK. Erk MAPK regulates phosphorylation of actin-related proteins such as cortactin, resulting in actin reorganization. (B) Schematic illustration of CORT-induced rapid thorn-genesis via multiple kinase pathways.
