. Author manuscript; available in PMC: 2013 Nov 27.

Published in final edited form as: Front Biosci (Schol Ed). 2012 Jan 1;4:1088–1098. doi: 10.2741/s320

Table 1.

Expression of putative sensory proteins in motile cilia

Gene name	Receptor class	Location of motile cilia	Stimulus or Sensor	Effect	References
TRPV4	Transient receptor potential (vanilloid) calcium channel	Airway, oviduct	Osmotic, viscosity, fluid flow	Increase Ca(i), regulate CBF	(34–36)
PR	Sex hormone receptor	Oviduct	Ligand binding	Increase Ca(i) Regulate CBF	(43–46, 71)
VANGL2	Planar cell polarity	Ependyma	Fluid flow	Orient basal bodies	(50)
T2R	Bitter taste receptors,	Airway	Bitter substance	Increase Ca(i) regulate CBF	(39)
PKD1	Polycystin trans-membrane protein	Airway, ependymal oviduct	Putative mechanosensory	Increase Ca(i)	(57, 59)
PKD2	Transient receptor potential calcium channel	Airway, oviduct	Putative mechanosensory	Increase Ca(i)	(58)

CBF, cilia beat frequency; Ca(i), intracellular calcium