. Author manuscript; available in PMC: 2013 Nov 27.

Published in final edited form as: Wound Repair Regen. 2012 Oct 30;20(6):10.1111/j.1524-475X.2012.00852.x. doi: 10.1111/j.1524-475X.2012.00852.x

Table 2.

Extracellular (patch) variables in the IVSABM. A summary of the variables encoded to the extracellular environment in the IVSABM. These variables include diffusible mediators and components of the SECM.

Patch Variable	Description	Effect in IVSABM
DAMPs/ROS	Induced by wounding	Binds to TLR-4
ATP	Induced by wounding	Binds to P2Y
Adenosine	Converted from ATP by CD73 in hypoxia	Binds to A2B
TGF-β	Induced by ROS	Activates LM-332 secretion
LM-511	Matrix component; constitutive	Leads to Rho-A
LM-332	Matrix component; induced by TGF-β	Leads to Rac1
EGF	Growth factor; present in serum-based media and released from membrane by ADAM-17	Binds to EGFR