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. Author manuscript; available in PMC: 2013 Nov 27.
Published in final edited form as: Hypertension. 2011 Nov 7;59(1):10.1161/HYPERTENSIONAHA.111.173328. doi: 10.1161/HYPERTENSIONAHA.111.173328

Figure 3. IL-6 promotes chronic renal fibrosis in Ang II-infused mice.

Figure 3

(A) H&E and Trichrome staining showed that Ang II-infused mice displayed kidney damage and fibrosis on day 14 of Ang II infusion. Genetic deletion of IL-6 significantly reduced vascular damage and fibrosis. Scale bars=200μm. (B) Quantitative image analyses showed Ang II-infused mice exhibited increased collagen staining in the kidney. Genetic deletion of IL-6 significantly decreased collagen staining in the kidney of Ang II-infused mice. (C) Collagen content in the kidney was significantly increased in Ang II-infused mice. Genetic deletion of IL-6 significantly decreased collagen content in the kidneys of Ang II-infused mice. Data are expressed as mean ± s.e.m. (n=6). *P < 0.05 versus WT mice. **P < 0.05 versus Ang II-infused WT mice.