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. Author manuscript; available in PMC: 2014 Oct 24.
Published in final edited form as: Cell. 2013 Oct 10;155(3):10.1016/j.cell.2013.09.046. doi: 10.1016/j.cell.2013.09.046

Figure 1. Expression and requirement of Sdf1a and its receptors Cxcr4b, Cxcr7a and Cxcr7b during primordium migration.

Figure 1

(A) Live images of embryos of the indicated stage and genotype. Arrow indicates the primordium, arrowheads indicates neuromasts. (B) Fluorescent staining for cxcr4b, cxcr7a or cxcr7b mRNA and GFP protein at 36 hpf. Scale bar 50 μm. (C) Fluorescent staining for sdf1a mRNA and GFP protein in a tg(cldnB:lyn2GFP) embryo at 36 hpf. Anterior is to the left and posterior is to the right. (D) Quantification of primordium migration in 48 hpf embryos of indicated genotypes. The vertical bars represent the average position of the primordium, the error bars represent SD and the circles represent the positions of individual primordia. 48 hpf embryo schematic adapted from (Kimmel et al., 1995). (See also Figure S6).