Table S1.
Comparison between groups at each time point and over all time points (repeated-measures analysis of variance)
| Baseline
|
6 weeks
|
3 months
|
6 months
|
P-value | |||||
|---|---|---|---|---|---|---|---|---|---|
| NPPV | Controls | NPPV | Controls | NPPV | Controls | NPPV | Controls | ||
| FEV1 %pred | 30.3 (7) | 29.6 (7.4) | 32.2 (11.8) | 31.5 (6.4) | 31.2 (11.9) | 31 (7.8) | 0.81 | ||
| FVC %pred | 68.8 (14.1) | 59.4 (8) | 74.2 (19.2) | 62.8 (8.8) | 71.9 (16.7) | 60.8 (30.2) | 0.97 | ||
| NIF (cm H2O) | −48.9 (14.5) | −63.2 (23.9) | −59.7 (24.1) | −64.5 (23.9) | −55.9 (20.3) | −63 (21.9) | 0.16 | ||
| PaCO2 (mmHg) | 42.4 (5.6) | 41.9 (4.6) | 44.1 (7) | 42.7 (4) | 44.3 (8.5) | 42.9 (4.5) | 0.92 | ||
| PaO2 (mmHg) | 65.1 (13.3) | 73.9 (9.9) | 62.1 (15.2) | 66.7 (10.5) | 67.2 (14.4) | 66.8 (9.9) | 0.12 | ||
| 6MWD (m) | 284 (101) | 321 (91) | 312 (110) | 320 (94) | 295 (101) | 335 (90) | 280 (142) | 304 (129) | 0.50 |
| CRQ score | |||||||||
| Dyspnea | 3.8 (1) | 3.7 (1) | 4.1 (0.9) | 3.7 (1.4) | 3.9 (0.8) | 3.6 (1.3) | 4.1 (1.2) | 3.4 (0.9) | 0.64 |
| Fatigue | 4.3 (1) | 4.1 (1) | 4.5 (0.9) | 3.9 (1.2) | 4.4 (1) | 4.1 (1.1) | 4.6 (1.3) | 4.2 (0.9) | 0.39 |
| Emotional function | 5.5 (0.7) | 5.3 (1.1) | 5.6 (0.7) | 5.1 (1.1) | 5.5 (0.9) | 5.2 (1.3) | 5.6 (1.1) | 5.3 (1.3) | 0.37 |
| Mastery* | 5 (1.1) | 5.3 (1.4) | 5.5 (1) | 5 (1.6) | 5.6 (1) | 5.2 (1.2) | 5.6 (1) | 5.2 (1.2) | 0.047 |
| Dyspnea | |||||||||
| TDI-Function | 1.9 (0.7) | 1.5 (0.7) | 0.6 (0.9)* | −0.3 (1.1) | 0.4 (0.8)* | −0.2 (0.4) | 0 (0.8) | −0.2 (0.7) | 0.31 |
| TDI-Task | 1.3 (0.5) | 1.4 (0.7) | 0.3 (0.5) | −0.3 (0.6) | 0.4 (0.5)* | −0.3 (0.9) | 0.5 (0.7)* | −0.3 (0.7) | 0.07 |
| TDI-Effort | 1.3 (0.5) | 1.3 (0.5) | 0.3 (0.5)* | −0.3 (0.6) | 0.4 (0.5)* | −0.1 (0.7) | 0.5 (0.7)* | −0.3 (0.7) | 0.13 |
| TDI total | 4.5 (1.6) | 4.2 (1.5) | 1.3 (1.9)** | −0.8 (1.9) | 1.3 (1.7)* | −0.3 (0.9) | 0.9 (2) | −0.5 (2.3) | 0.28 |
Notes: All results expressed as the mean (standard deviation).
*
P<0.05 and
**
P<0.01.
Abbreviations: FEV1, forced expiratory volume in the first second; %pred, percent predicted; FVC, forced vital capacity; NIF, negative inspiratory force; NPPV, noninvasive positive pressure ventilation; PaCO2, partial pressure of carbon dioxide in arterial blood; PaO2, partial pressure of oxygen in arterial blood; 6MWD, six-minute walk distance; CRQ, Chronic respiratory Disease Questionnaire; TDI, Transitional Dyspnea Index at baseline.