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. Author manuscript; available in PMC: 2013 Nov 27.
Published in final edited form as: Cancer Gene Ther. 2012 May 4;19(6):10.1038/cgt.2012.22. doi: 10.1038/cgt.2012.22

Figure 2. Schematic illustration of siRNA delivery with multistage vector.

Figure 2

(a) The 1st stage porous silicon loaded with siRNA nanoparticles travels in the circulation, and attaches to the tumor vascular endothelium. (b) The 1st stage particle releases 2nd stage carrier nanoparticles through the vascular endothelium into tumor interstitium where they are taken up by tumor cells. (c) Possible routes of siRNA entry into tumor cells.