Table 3. Association studies for TNFB gene +252 A/G polymorphism in different clinical types of vitiligo patients and controls from Gujarat.
| SNP | Genotype or allele | Generalized Vitiligo Patients(Freq.) | LocalizedVitiligo Patients(Freq.) | Controls(Freq.) | p for Association | p for HWE | Odds ratio(95% CI) |
| rs909253(+252 A/G) | GenotypeAAAGGGAlleleAG | n = 360184 (0.51)137 (0.38)39 (0.11)505 (0.70)215 (0.30) | n = 164103 (0.63)51 (0.31)10 (0.06)257 (0.78)71 (0.22) | n = 592375(0.63)188(0.32)29 (0.05)938(0.79)246(0.21) | 0.030a<0.0001b0.826c0.006a<0.0001b0.759c | 0.083(GV)0.286(LV)0.389(Controls) | 1.541a (1.133–2.096)1.623b (1.312–2.008)1.053c (0.782–1.419) |
| rs909253(+252 A/G) | GenotypeAAAGGGAlleleAG | ActiveVitiligo(Freq.)n = 393201 (0.51)152 (0.39)40 (0.10)554 (0.70)232 (0.30) | StableVitiligo(Freq.)n = 13185 (0.65)40 (0.30)6 (0.05)210 (0.80)52 (0.20) | Controls(Freq.)n = 592375 (0.63)188 (0.32)29 (0.05)938(0.79)246(0.21) | 0.012d<0.0001e0.945f0.002d<0.0001e0.800f | 0.163(AV)0.645(SV)0.389(Controls) | 1.691d (1.204–2.376)1.597e (1.297–1.966)0.944f (0.676–1.319) |
‘n’ represents number of patients/controls, HWE refers to Hardy-Weinberg Equilibrium, CI refers to confidence interval, GV refers to generalized vitiligo, LV refers to localized vitiligo, AV refers to active vitiligo, SV refers to stable vitiligo,
a
generalized vitiligo vs. localized vitiligo,
b
generalized vitiligo vs. controls,
c
localized vitiligo vs. controls,
d
active vitiligo vs. stable vitiligo,
e
active vitiligo vs. controls,
f
stable vitiligo vs. controls, values are significant at p≤0.025 due to Bonferroni's correction.