Figure 2. The number and size of breast tumors in PyMT mice correlated with distance run.

A. Distance run at 3 weeks was associated with the number of palpable tumors during the 3rd week (Pearson's r = −0.6, p = 0.051, R² = 0.36), B, total tumor sizes (Pearson's r = −0.6, p = 0.0504, R² = 0.36), and C, anterior tumor sizes (glands 1–3) (Pearson's r = − 0.61, p = 0.044, R² = 0.38). D. High volume runners demonstrated significantly smaller tumor sizes compared with non-runners during the 3rd week (p<0.05), but not with low volume runners. E. Distance ran at 3 weeks was correlated with total tumor size in runners during the 5th week (Pearson's r = −0.65, p = 0.023, R² = 0.42). F. Distance run at 4 weeks was correlated with total tumor size in runners during the 5th week (Pearson's r = −0.57, p = 0.054, R² = 0.32).