Figure 4. Both beneficial and detrimental effects of Hsp90 inhibitors on cancer-related proteins.

Cancer proteins categorized by Higgins et al. [46] as oncogenes or tumour suppressors were retrieved and identified in the stSILAC data. These results were further refined and confirmed by literature mining, and organized in a protein-protein interaction network. Relative levels of proteins at 20hs after GA treatment are integrated in the graph and represented by the same colour gradient as in Fig. 2.