Figure 3. Results of two-component PLS-DA models built on succinate, glutamate, glutathione, and energy phosphorylated compounds (ATP/ADP/AMP) according to the patients' genotypes: A) 3-class model including apparently sporadic (black dots), SDHx- (green dots), and VHL-related tumors (yellow dots); B) 2-class model including apparently sporadic and SDHx-related tumors; C) 2-class model including apparently sporadic and VHL-related tumors; D) 2-class model including SDHx- and VHL-related tumors.

A clear distinction between the different classes of tumors is shown in each model.