Table 1. Median values and ranges of succinate, glutathione, glutamate, and ATP/ADP/AMP levels measured by 1D ¹H-HRMAS spectroscopy in intact tissue samples of 28 apparently sporadic, SDHx, and VHL-related PHEOs/PGLs. Quantification results are expressed as nmol/mg of tissue.

	Sporadic	SDHx	VHL	P Sporadic vs SDHx	P Sporadic vs VHL	P SDHx vs VHL
Succinate	0.03 (0–0.06)	3,6 (0.9–9.07)	0.06 (0.03–0.12)	0.000003	0.02	0.0001
Glutathione	0.04 (0.03–0.22)	0.15 (0.05–0.39)	0.32 (0.17–0.43)	0.01	0.003	0.08
Glutamate	1.36 (0.23–2.55)	0.67 (0.13–1.52)	1.49 (0.88–2.18)	0.003	1	0.0007
ATP/ADP/AMP	0.10 (0.03–0.18)	0.05 (0–0.21)	0.16 (0.06–0.29)	0.1	0.1	0.01