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. 2013 Nov 27;8(11):e81537. doi: 10.1371/journal.pone.0081537

Table 1. Model parameters used in the simulations.

Parameter Variable Value
Flow Rate (µL/min) Q 7.8
Device Height (µm) H 100
Device Width (µm) w 1500
Plasma Viscosity [12] (Pa.s) μp 0.001
Plasma Layer Position (µm) yi 49
Slip Coefficient [11] slp 0.1
Discharge Hematocrit HD 0.2
Plasma Layer Thickness (µm) τ 1
O2 Diffusivity in Plasma [11] (µm2/s) Dp 2750
O2 Solubility in RBCs [11] (µM/mmHg) KRBC 1.47
O2 Solubility in Plasma [11] (µM/mmHg) Kp 1.33
Total Heme Concentration [11] (µM) [HbT] 5350
Inlet PO2 (mmHg) P0 150
O2 Permeable Membrane PO2 (mmHg) Pb 10
O2 Permeable Membrane Start Position (µm) a 7000
O2 Permeable Membrane End Position (µm) b 7700
Device Length (µm) L 14000
O2 Diffusivity in O2 Permeable Membrane (µm2/s) Dm 160000
O2 Solubility in O2 Permeable Membrane (µM/mmHg) Km 17.959
O2 Permeable Membrane Thickness (µm) T 100
Hill Coefficient [11] N 2.7
Partial Pressure at 50% Saturation [11] (mmHg) P50 27
Minimum ATP Release Rate (µM/s) Rmin 0
Maximum ATP Release Rate (µM/s) Rmax 14
ATP Release Time (s) td 0
ATP Diffusivity in Plasma [16] (µm2/s) DATP 475
ATP/Luciferin Reaction Rate [8] (s−1) kt 0.1
Quantum Efficiency [8] α 0.88
Shutter Speed (s) ts 10
Pixel Surface Area* (µm2) Apixel 166.41
Plasma Attenuation Coefficient (µm−1) κp 0.1
Oxyhemoglobin Attenuation Coefficient** (µm−1) κO2Hb 0.040176
Hemoglobin Attenuation Coefficient** (µm−1) κHb 0.066261
Camera Efficiency* η 0.7
Full Well Capacity* (electrons) FWC 22000

Uits are given in the first column. One asterisk (*) indicates parameters taken from the specification of Qimaging's Rolera XR camera.

Two asterisks (**) indicates parameters calculated from tabulated molar extinction coefficients for hemoglobin in water at 560 nm; these values were compiled by Scott Prahl (prahl@ece.ogi.ed).