Table 2. Determination of the genetic effect of APOE ε2/ε3/ε4 polymorphism on POAG and subgroup analyses.
| Genetic Contrasts | Comparisons | Studies (n) | Heterogeneity test |
Model selected | OR(95%CI) | |
|---|---|---|---|---|---|---|
| P value | I2 | |||||
| ε2 vs ε3 | Overall | 9 | 0.217 | 25.4 | Fixed | 1.034 (0.871,1.227) |
| Caucasian | 3 | 0.23 | 32 | Fixed | 1.118 (0.827,1.513) | |
| Asian | 5 | 0.213 | 31.3 | Fixed | 1.038 (0.835,1.290) | |
| ε4 vs ε3 | Overall | 9 | 0 | 72.5 | Random | 0.965(0.700,1.329) |
| Caucasian | 3 | 0.592 | 0 | Fixed | 1.045(0.807,1.353) | |
| Asian | 5 | 0 | 81.6 | Random | 0.913(0.540,1.544) | |
| ε2/2 vs ε3/3 | Overall | 9 | 0.992 | 0 | Fixed | 0.950(0.482,1.871) |
| Caucasian | 3 | 0.727 | 0 | Fixed | 0.870(0.280,2.705) | |
| Asian | 5 | 0.932 | 0 | Fixed | 1.046(0.363,3.018) | |
| ε2/3 vs ε3/3 | Overall | 9 | 0.037 | 51.3 | Random | 0.964(0.706,1.317) |
| Caucasian | 3 | 0.265 | 24.7 | Fixed | 1.092(0.758,1.574) | |
| Asian | 5 | 0.053 | 57.1 | Fixed | 1.060(0.830,1.355) | |
| ε2/2 + ε2/3 vs ε3/3 | Overall | 9 | 0.059 | 46.6 | Fixed | 1.025(0.842,1.248) |
| Caucasian | 3 | 0.24 | 30 | Fixed | 1.063(0.742,1.523) | |
| Asian | 5 | 0.052 | 57.5 | Fixed | 1.062(0.832,1.356) | |
| ε2/2 vs ε3/3 + ε2/3 | Overall | 9 | 0.994 | 0 | Fixed | 0.979(0.499,1.920) |
| Caucasian | 3 | 0.761 | 0 | Fixed | 0.858(0.276,2.664) | |
| Asian | 5 | 0.94 | 0 | Fixed | 1.028(0.358,2.955) | |
| ε4/4 vs ε3/3 | Overall | 9 | 0.641 | 0 | Fixed | 1.339(0.763,2.350) |
| Caucasian | 3 | 0.807 | 0 | Fixed | 1.561(0.723,3.375) | |
| Asian | 5 | 0.698 | 0 | Fixed | 1.663(0.642,4.309) | |
| ε3/4 vs ε3/3 | Overall | 9 | 0.001 | 69.7 | Random | 0.917(0.637,1.321) |
| Caucasian | 3 | 0.839 | 0 | Fixed | 0.879(0.635,1.215) | |
| Asian | 5 | 0.001 | 78.4 | Random | 0.852(0.491,1.476) | |
| ε3/4 + ε4/4 vs ε3/3 | Overall | 9 | 0.001 | 70.4 | Random | 0.938(0.655,1.342) |
| Caucasian | 3 | 0.799 | 0 | Fixed | 0.930(0.681,1.270) | |
| Asian | 5 | 0 | 80.6 | Random | 0.893(0.503,1.586) | |
| ε4/4 vs ε3/3 + ε3/4 | Overall | 9 | 0.621 | 0 | Fixed | 1.325(0.757,2.321) |
| Caucasian | 3 | 0.805 | 0 | Fixed | 1.604(0.745,3.453) | |
| Asian | 5 | 0.834 | 0 | Fixed | 1.637(0.632,4.236) | |
OR, odds ratio; CI, confidence interval.