Table 3. Genotype frequencies of three BCHE markers in cocaine-dependent patients, by preferred form of cocaine administration.
| Genotype | n | χ2 | P | |||
| SNP/Subgroup | AA | AG | GG | |||
| rs1803274a | ||||||
| Powder cocaine users, n (%) | 4 (2.6) | 45 (29.0) | 106 (68.4) | 155 | ||
| Crack users, n (%) | 6 (10.6) | 14 (24.1) | 38 (65.5) | 58 | ||
| Dual users, n (%) | 8 (1.7) | 142 (30.7) | 313 (67.6) | 463 | ||
| Total, n (%) | 18 (2.7) | 201 (29.7) | 457 (67.6) | 676 | 15.20 | 0.004 |
| rs4680662 | ||||||
| Powder cocaine users, n (%) | 16 (10.1) | 77 (48.7) | 65 (41.1) | 158 | ||
| Crack users, n (%) | 4 (6.6) | 29 (47.5) | 28 (45.9) | 61 | ||
| Dual users, n (%) | 55 (11.7) | 211 (44.9) | 204 (43.4) | 470 | ||
| Total, n (%) | 75 (10.9) | 317 (46.0) | 297 (43.1) | 689 | 2.10 | 0.718 |
| rs4263329 | ||||||
| Powder cocaine users, n (%) | 107 (68.2) | 46 (29.3) | 4 (2.5) | 157 | ||
| Crack users, n (%) | 46 (76.7) | 13 (21.7) | 1 (1.7) | 60 | ||
| Dual users, n (%) | 344 (73.5) | 121 (25.9) | 3 (0.6) | 468 | ||
| Total, n (%) | 497 (72.6) | 180 (26.3) | 8 (1.2) | 685 | 5.48 | 0.241 |
a
rs1803274 AA genotype, P = 0.027; OR = 4.36 (95% confidence interval = 1.18–16.04), between crack users and powder users.