Figure 2. Penetrance of 5-FAM tagged IC2B peptide into rat pulmonary artery tissue.
Ex vivo vessel tissues were imaged with a fluorescence microscope at 40X magnification after treating with medium containing 5-FAM tagged IC2B peptide (A) or sham (B) for 1 hr. In vivo penetrance was determined by taking images of normal rat lung with no injected IC2B-FAM (C), a lung from a rat IP injected with the IC2B 5-FAM (D,E). Arrows show staining of SMC in airways and large vessels (D) and small arterioles (E).