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Hypothetical model for fesselin binding, polymerization and bundling of actin. Actin monomers are drawn with barbed and pointed ends to illustrate the asymmetry of the two ends of actin filaments. Fesselin binds to about 4 actin protomers; nucleation is shown as a complex of fesselin with 3 actin monomers. Actin and actin-fesselin add rapidly to nuclei to form filaments. These filaments bundle, perhaps as a result of fesselin spanning parallel filaments.
