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. 2013 Nov 21;4(9):727–735. doi: 10.7150/jca.7576

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© Ivyspring International Publisher. This is an open-access article distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited.

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Fig 4 — Downregulated SRPK1 increases chemotherapeutic drug resistance of glioma cells in normoxic and hypoxic condition. (A) Viability of U251 cells exposed to different concentrations of DDP for 24,48,72 h. The results are presented as percentage (mean±SD). Cell viability was evaluated by MTT assay. (B) Viability of U251 cells exposed to different concentrations of TMZ for 24,48,72 h. The results are presented as percentage (mean±SD). Cell viability was evaluated by MTT assay. (C) Bar graph showing the different of cell apoptotic rates between the control and siSRPK1 (* P<0.05, ** P<0.01, n=3, ANOVA) U251 cells treated by DDP or TMZ in normoxic or hypoxic condition(compared with no treatment). (D) U251 cells were transfected for 24h with scramble SRPK1 siRNAs and treated or not for an additional 48 h with 200 uM TMZ or 20ug/ml DDP. Cell apoptotic rates were analyzed by flow cytometry.