APPENDIX 2.

Stroke Imaging Protocol

Standardized MRI Protocol Diffusion-weighted imaging Gradient-recalled echo or susceptibility-weighted imaging T2-weighted FLAIR Contrast-enhanced MR angiography (first injection) Dynamic susceptibility contrast perfusion MRI (second injection) Contrast-enhanced T1-weighted sequence

General Parameter Recommendations Minimum slice thickness 5 mm Contrast-enhanced MR angiography injection: 0.05 mmol at 2 mL/s Dynamic susceptibility contrast perfusion MRI injection: 0.5 mmol at 5 mL/s

Alternative Protocol Time-of-flight MR angiography and arterial spin labeling in combination