Figure 5.

Aβ-induced depression and LTD impairment is prevented by inhibition of JNK and p38 MAPK. A, Treatment of slices with 1 μm SB203580 and 20 μm SP600125 (black diamond and white circles, respectively); application of 1 μm Aβ(1-42) for 10 min (dark bar) was unable to induce synaptic depression. B, LFS-induced LTD was completely abolished by p38 MAPK inhibition with SB203580 (1 μm; gray squares) but was normally expressed in slices after JNK inhibition with SP600125 (20 μm; gray circles). C, SP600125 treatment rescued a normal LTD in slices after 1 μm Aβ exposure (for 10 min; dark bar). Error bars indicate SEM.