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Spinal inhibition and targeted mutation of MMP-9 attenuate behavioral signs of naloxone-precipitated morphine withdrawal. A, B, Overall withdrawal scores (A) were calculated from the individual signs (B). *p < 0.05, **p < 0.01 compared to the control (Ctrl) group in WT or MMP-9 mutation (Mmp9−/−) group. Number of mice in each group: WT Ctrl = 20, WT MMP9i = 10, Mmp9−/− Ctrl = 15, Mmp9−/− MMP9i = 10.
