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. 2010 Sep 15;30(37):12379–12386. doi: 10.1523/JNEUROSCI.1295-10.2010

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Copyright © 2010 the authors 0270-6474/10/3012379-08$15.00/0

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Figure 4. — Stimulation of M-type K⁺ channels with flupirtine reduced the intrinsic excitability of IL pyramidal neurons. A, Traces showing the number of spikes evoked by a current pulse during baseline, perfusion with the M-type K⁺ channel agonist (flupirtine, 30 μm) and washout. B, C, Time course and bar graph showing that flupirtine application decreased the number of evoked spikes in IL pyramidal neurons (n = 6). D, Flupirtine also increased the interspike intervals, consistent with reduced bursting in IL. (**p < 0.001).