Figure 6.

Infusions of flupirtine into the PL before extinction training reduced fear expression. A, Diagram showing the location of the cannula tips in PL for the vehicle (white circles) and flupirtine (black circles) groups. B, Freezing to the tone for vehicle-infused rats (n = 6) and rats infused with flupirtine (30 μm, n = 6). Flupirtine-infused rats showed reduced fear expression on day 2. No significant difference between the groups was observed on days 3–5. The arrow indicates the time of the infusion. *p < 0.05.