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Phylogenetic relationship of Human MTHFR protein sequence (P42898) with MTHFR protein sequence of 15 selected species. The phylogram shows that Human MTHFR posseses greater similarity with Macaca fascicularis (SwissProt ID: Q60HE5). Only two structures of MTHFR from the selected species are experimentally determined having their structures available in the Protein Data Bank. These two species are E. coli (PDB code: 1b5t) and Thermus thermophilus (PDB code: 1v93).
