Skip to main content
. Author manuscript; available in PMC: 2013 Nov 28.
Published in final edited form as: Nat Neurosci. 2008 Oct 8;11(12):10.1038/nn.2220. doi: 10.1038/nn.2220

Figure 6.

Figure 6

Adult OLPs do not generate astrocytes. Sections of P45 + 90 Pdgfra-creERT2/Rosa26-YFP mice were immunolabeled for YFP and GFAP. (a–d) No double-labeled cells were observed anywhere in the corpus callosum or cortex. Sections were also immunolabeled for YFP and S100β, a marker of protoplasmic astrocytes and some oligodendrocyte lineage cells. (e) In cortex, some YFP+ S100β+ cells were present, but these invariably colabeled for PDGFRA (yellow arrow), identifying them as OLPs. (f) In the corpus callosum, all of the YFP+ S100β+ cells were SOX10+ (yellow arrow in f). The white arrow in f indicates a YFP−,SOX10+ S100β+ oligodendrocyte lineage cell and the white arrowhead indicates a YFP− SOX10−,S100β+ presumptive astrocyte. Scale bars represent 10 μm in b and e, and 25 μm in a, c, d and f.