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Variable combinations of α6β4 and α3β4 nAChRs are expressed together. The two traces shown are from mouse DRG neurons. Similar results were obtained with rat DRG neurons. In all of the β4-expressing neurons, responses to ACh were partially blocked by 500 nM BuIA[T5A;P6O], which selectively blocks α6β4 over α3β4 nAChRs (see Table 1). The bottom trace illustrates greater block by BuIA[T5A;P6O] than the top trace.
