FIGURE 6.
A subset of non-neuronal DRG cells express muscarinic acetylcholine receptors (mAChRs). The three traces shown are from mouse DRG cells. Similar results were obtained with rat DRG cells. The bottom trace is from a non-neuronal DRG cell that did not respond to depolarization by 30 mM [K+]o (K), but did respond to applications of 1 mM ACh. Notably, the ACh-elicited responses in this cell were not blocked by BuIA, but were blocked by 1 μM atropine, an antagonist of mAChRs. In contrast to the bottom trace, the top two traces are from DRG neurons that responded to depolarization by 30 mM [K+]o. The top trace is from the DRG neuronal subclass that expresses α7 nAChRs and the middle trace is from the α3β4/α6β4-expressing subclass.