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. 2013 Nov 28;7:225. doi: 10.3389/fncel.2013.00225

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Copyright © 2013 Smith, Hone, Memon, Bossi, Smith, McIntosh, Olivera and Teichert.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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A subset of non-neuronal DRG cells express muscarinic acetylcholine receptors (mAChRs). The three traces shown are from mouse DRG cells. Similar results were obtained with rat DRG cells. The bottom trace is from a non-neuronal DRG cell that did not respond to depolarization by 30 mM [K⁺]_o (K), but did respond to applications of 1 mM ACh. Notably, the ACh-elicited responses in this cell were not blocked by BuIA, but were blocked by 1 μM atropine, an antagonist of mAChRs. In contrast to the bottom trace, the top two traces are from DRG neurons that responded to depolarization by 30 mM [K⁺]_o. The top trace is from the DRG neuronal subclass that expresses α7 nAChRs and the middle trace is from the α3β4/α6β4-expressing subclass.