Figure 5.
Electron microscopy features of endocrine cells in duodenal biopsy from patients with PC1/3 deficiency and control.
(A) Classical enterochromaffin-type cell in duodenum of patient with PC1/3 deficiency showing well preserved ultrastructure including pleiomorphic electron-dense secretory granules (arrow), mitochondria (mi)and nucleus (Nu). (B) Different subtype of enteroendocrine cell in same biopsy as Fig A with spherical electron-dense granules (arrow) and well preserved cytoplasmic organelles including mitochondria (mi) and nucleus (Nu). (C) Enterochromaffin-type cell in duodenum of control showing similar ultrastructural features as in Fig A. (Magnification bar for A, B&C, 2 microns).