Table 1.
Patient characteristic
| MA.20[16] | EORTC[17] | French[15] | |
|---|---|---|---|
|
Recruitment years |
2000-2007 |
1996-2004 |
1991-1997 |
|
Number of patients |
1832 |
4004 |
1334 |
|
Median age |
54 |
54 |
57 |
|
Node positive |
85% |
56% |
75% |
|
Breast surgery |
100% breast conserving |
75% breast conserving |
100% mastectomy |
|
CHX |
91% |
85% |
61% |
|
ER/PR negative |
25% |
16% |
7% |
|
Unknown ER/PR status |
n.a. |
6% |
40% |
|
Main inclusion criteria |
N + or high risk* N0 any location |
N + or medial/central tumor |
N + or medial/central tumor |
|
Breast/chest wall |
Both arms: 50 Gy / 25 fx |
Both arms 50 Gy / 25 fx |
Both arms according to practice of the center |
|
Medial supraclavicular nodes |
Experimental arm: 45 Gy / 25 fx |
50 Gy / 25 fx |
All patients: dose and fractionation according to practice of the center |
| Internal mammary nodes | Experimental arm: 45 Gy / 25 fx | Experimental arm: 50 Gy / 25 fx | Experimental arm: 45 Gy / 20 fx |
*= > = 5 cm tumor, > = 2 cm tumor, and <10 axillary nodes removed with ER-, G3, or lymph vacular invation; n.a. = not available; fx = fractions; ER = estrogene receptor; PR = progesterone receptor.