Table 1. Comparison of the inhibitory effects of meleagrin (1) and its derivatives against Staphylococcus aureus and E. coli FabI, bacterial growth, and [¹⁴C] acetate and [¹⁴C] leucine incorporation into membrane fatty acids.

Compounds	IC50 (μM)			MIC (μg/mL)			IC50 (μM)
	saFabI	ecFabI	spFabK	S. aureus a	E. coli b	S. pneumoniae c	[14C] acetate incorporation	[14C] leucine incorporation
1	40.1	33.2	>200	64	32	64	40.3	>200
2	54.6	49.7	>200	64	64	64	-	-
3	38.7	38.8	>200	64	32	64	33.5	>200
4	48.0	33.1	>200	64	32	64	35.7	>200
5	13.5	15.6	>200	16	8	16	16.3	>200
6	13.1	15.4	>200	16	8	16	19.8	>200
7	>200	>200	>200	>128	>128	>128	>200	>200
Triclosan	0.66	0.98	>200	0.01	0.01	64	0.04	>10

^a S. aureus RN4220; ^b E. coli KCTC 1924; ^c S. pneumoniae KCTC 3932.