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. 2013 Dec 1;24(23):3736–3745. doi: 10.1091/mbc.E13-07-0408

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© 2013 Krajcovic et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

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FIGURE 5: — Model for phagosome and entotic vacuole fission. The degradation of cell corpses after phagocytosis or entosis recruits mTORC1 (yellow) to Lamp1-positive (green) vacuole membranes. mTORC1 regulates vacuolar fission, which redistributes the luminal contents of phagosomes and entotic vacuoles into the lysosome network of engulfing cells. mTORC1-regulated fission (thick arrow) accelerates vacuole shrinkage by overcoming a constant rate of lysosome fusion (thin arrow). Amino acid export from phagosomes and entotic vacuoles likely provides the survival advantage of engulfing cells in amino acid–free media.