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. 2013 Oct 4;288(48):34414–34426. doi: 10.1074/jbc.M113.508812

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© 2013 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 5. — Effect of cholesterol and phospholipids on the transport activity of ABCA1 and ABCA4. A, Fl-PC transport activity of ABCA1 and Fl-PE transport activity of ABCA4 reconstituted in PG liposomes containing 0–30% (w/w) cholesterol (Chol). B, effect of PC, PE, and PI on the transport of Fl-PC by ABCA1 reconstituted into PG liposomes. Unlabeled PC and BPL effectively compete with Fl-PC for transport by ABCA1, whereas PI has little effect. C, effect of PC, PE, and PI on the transport of Fl-PE by ABCA4 reconstituted into PC liposomes. Unlabeled PE and BPL effectively compete with Fl-PE for transport by ABCA4, whereas PC and PI have little effect. Results are the mean ± S.D. for three independent experiments.