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. 2013 Oct 11;288(48):34470–34483. doi: 10.1074/jbc.M113.515668

FIGURE 6.

FIGURE 6.

Proposed binding mode for salvinorin A. A, putative interaction of salvinorin A with, among other residues, Ile316(7.39) and Ile290(6.51) in the KOR orthosteric binding site. Like U-69593, the close association of the ligand with TM7 probably interferes with the ability of TM7 to adopt a G protein-recognizing conformation. B, putative binding mode showing KOR amino acid residues within 4 Å of the ligand. Water molecules W1–W4 correspond to Wat1311, -1307, -1316, and -1314, respectively.