FIGURE 1.

Involvement of argininosuccinate lyase in various metabolic and biochemical pathways. Shown is a schematic illustration of the involvement of ASL in various metabolic and biochemical reactions. Colors are used to show the affiliation of metabolites and enzymes to different pathways: urea cycle (blue), nitric oxide synthesis (gold), polyamine synthesis (maroon), and creatine synthesis (purple). Enzymes are depicted in ovals: arginine decarboxylase (ADC), arginine:glycine amidinotransferase (AGAT), arginase (ARG); argininosuccinate lyase (ASL), argininosuccinate synthetase (ASS), carbamoylphosphate synthetase 1 (CPS1), guanidinoacetate methyltransferase (GAMT), nitric-oxide synthase (NOS), ornithine decarboxylase (ODC), and ornithine transcarbamylase (OTC).