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. Author manuscript; available in PMC: 2013 Nov 29.
Published in final edited form as: Oncogene. 2010 Jun 7;29(33):10.1038/onc.2010.206. doi: 10.1038/onc.2010.206

Figure 2. ACL generates a nuclear/cytosolic pool of acetyl-CoA in mammals.

Figure 2

In times when glucose is around, TCA-derived citrate can be converted into aceteyl-CoA by ACL, both in the nucleus and cytosol, thereby providing a nuclear/cytosolic pool of acetyl-CoA. This pool of acetyl-CoA, which seems to be independent of the mitochondrial acetyl-CoA pool, is used for histone acetylation by histone acetyltransferases, such as GCN5.