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. Author manuscript; available in PMC: 2013 Nov 29.
Published in final edited form as: Oncogene. 2010 Jun 7;29(33):10.1038/onc.2010.206. doi: 10.1038/onc.2010.206

Figure 3. Energy sensing mediated by cofactors.

Figure 3

In times of high energy demand, an AMPK-mediated increase in NAD+ activates Sirt1 resulting in the deacetylation and activation of PGC-1α leading ultimately to mitochondrial biogenesis and improved mitochondrial function. Conversely, GCN5-mediated acetylation inactivates PGC-1α when plenty of energy is around. The acetyl-CoA necessary for this acetylation reaction is provided by ACL, which acts as rate limiting for this reaction.