Fig. 1.

Survival of irradiated mice after PEG-HGF administration. Mice were exposed to radiation doses from 7.76 to 8.72 Gy and injected subcutaneously with either 0.1 mg kg⁻¹ day⁻¹, 0.3 mg kg⁻¹ day⁻¹, or 1.0 mg kg⁻¹ day⁻¹ PEG-G-CSF (BBT-015), PEG-GM-CSF (BBT-007), or PEG-IL-11 (BBT-059) 24+4 hours (1 dose), every other day from days 1 to 5 (3 doses), or every other day from day 1 to 17 (9 doses) post irradiation. Control mice were similarly injected with vehicle. Bars in Fig. 1 shows the percentage of PEG-HGF-treated mice that survived above vehicle-treated mice (% survival of treated mice minus % survival of control mice). Thirty day survival was significantly increased for all PEG-HGF-treated mice compared to vehicle treated mice, except for 0.1 mg/kg PEG-GM-CSF-treated mice (*p≤0.05, **p≤0.006, n=39–40 mice per group in each study).