Table 1.
Outcomes of artificial activation with calcium ionophore in patients with no- or low-fertilization history
| Characteristic | No fertilization | P | Low fertilization | P | ||
|---|---|---|---|---|---|---|
| Previous | AOA | Previous | AOA | |||
| No. of cycles | 98 | 98 | 72 | 72 | ||
| Female age | 35.34 ± 4.86 | 37.93 ± 5.42 | < 0.05 | 34.18 ± 4.33 | 36.96 ± 4.23 | < 0.001 |
| GnRH doses | 2400.69 ± 1591.35 | 2363.33 ± 1277.56 | 0.871 | 2368.91 ± 942.52 | 2575.00 ± 1166.80 | 0.250 |
| Retrieved oocytes | 9.88 ± 8.25 | 11.52 ± 7.39 | 0.145 | 8.50 ± 7.21 | 13.51 ± 8.54 | < 0.001 |
| Mature oocytes per retrieved oocytes | 4.48 ± .4.45 | 8.37 ± 5.69 | < 0.001 | 5.86 ± .4.65 | 9.43 ± 6.87 | < 0.001 |
| Fertilized embryos | 0 | 7.68 ± 5.07 (75.7 %) | < 0.001 | 2.92 ± 2.51 (34.8 %) | 8.00 ± 5.45 (68.2 %) | < 0.001 |
| Cleavage embryos on day 2 | 6.44 ± 4.36 | 2.58 ± 2.29 | 6.65 ± 4.48 | < 0.001 | ||
| High-quality embryos on day 3 | 2.39 ± 2.70 | 0.24 ± 0.49 | 2.25 ± 3.78 | < 0.001 | ||
| Transferred embryos | 3.18 ± 1.23 | 2.31 ± 1.79 | 3.40 ± 1.10 | < 0.001 | ||
| Clinical pregnancy | 32.7 % (32/98) | 5.6 % (4/72) | 23.6 % (17/72) | < 0.05 | ||
| Implantation | 15.4 % (48/312) | 1.7 % (4/238) | 9.4 % (23/245) | < 0.001 | ||
| Abortions (n) | 6 | 4 | ||||
| Delivery cycles (n) | 21 | 8 | ||||
| Lost follow-up (n) | 5 | 5 | ||||
Values are mean ± SD or rate; Clinical pregnancy: presence of G-sac/transferred cycle; Implantation: number of G-sacs/transferred embryos