Figure 1.

Schematic diagram for the roles of Treg subsets on B cell. Both nTreg and iTregs suppress Th cell response that is important for B cell activation. However, both Tregs also directly suppress B cell response through different mechanisms. While nTreg cells kill B cell through the secretion of Perforin and Granzyme B, iTreg cells suppress B cell response through immune suppressive cytokines including TGF-β and IL-10. Both Treg may have synergetic role on B cells to regulate the production of antibodies. It is unclear so far whether both Treg cell directly suppress plasma cells.